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Randomized phase II study of modified FOLFOX-6 in combination with ramucirumab or icrucumab as second-line therapy in patients with metastatic colorectal cancer after disease progression on first-line irinotecan-based therapy

Central nervous system appetite control Both semaglutide and tirzepatide cross the blood-brain barrier and act on appetite centers in the hypothalamus

Immunological remodeling The immune system typically identifies and destroys cancer cells, while cancer can evade immune detection through immunosuppression

Increasing before steady state means you do not actually know whether the current dose is sufficient