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Some people think that taking high doses of B12 rather than the recommended intake is best for their health
In some research contexts, observations have included mild and transient tolerability-related effects such as: Headaches Nausea Stimulation-related observations Temporary injection-site irritation or localized skin-response variability Research conditions, concentration ranges, dosage ranges, hydration status, administration frequency, and protocol structure may influence tolerability observations across experimental settings
therefore, calcium supplementation is not currently prescribed for the prevention or treatment of metformin-induced vitamin B 12 deficiency (145)
This active form regulates calcium and phosphate metabolism, supporting bone mineralisation
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