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Reaction mechanism [edit] GPX4 catalyzes the following reaction: 2 glutathione + lipidhydroperoxide glutathione disulfide + lipidalcohol + H 2 O This reaction occurs at the selenocysteine within the catalytic center of GPX4

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Identification of PAD2 as a gamma-glutamylcysteine synthetase highlights the importance of glutathione in disease resistance of Arabidopsis.

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