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[DOI] [PubMed] [Google Scholar] 4.Nauck MA, Quast DR, Wefers J, Meier JJ

It helps promote the body's own GLP-1 activity, supports balanced glucose metabolism, and contributes to longer-lasting satiety and better daily energy balance

(1) proopiomelanocortin (POMC) and cocaine-amphetamine-related constructs (CART) neurons activated by peripheral anorexigenic hormones and releasing a-melanocyte-stimulating hormone (alpha-MSH) in satiety center and (2) neurons activated by orexigenic peptides such as ghrelin and orexins that release the substances including neuropeptide Y (NPY), orexins and Agouti-related Peptide (AgrP) in hunger center

Individuals exposed to any GLP-1 RA had 68% lower odds of NUD compared to unexposed individuals (odds ratio OR = 0.32