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1 Your RA medications can continue as prescribed: Oral DMARDs (methotrexate, sulfasalazine, hydroxychloroquine, leflunomide) are unlikely to be affected, as semaglutide doesnt meaningfully change how much of these drugs your body absorbs Biologic DMARDs (adalimumab, etanercept, tocilizumab, rituximab) are given by injection or infusion, so they bypass the gut entirely JAK inhibitors (tofacitinib, baricitinib) are oral medications with no published interaction data, but the same reassurance applies Methotrexate Methotrexate is the cornerstone of RA treatment for most people

Over-the-counter remedies: If nausea is moderate, over-the-counter options like bismuth subsalicylate can help