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Class A (Avoid without specialist approval): Supplements with a pharmacodynamic mechanism directly overlapping isotretinoin's known CNS effects, including 5-HTP, St

The medial femoral condyle is the most commonly treated and tends to yield better outcomes compared to the patellofemoral compartment, which presents with complex biomechanics and greater shear forces during flexion (Trattnig et al., 2011)

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