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For example, in a 16-week, placebo-controlled trial of an age-advanced cohort receiving nightly subcutaneous GHRH analogue (a sermorelin-like peptide), treatment activated endogenous GH pulsatility and significantly increased integrated nocturnal GH levels

Combining Ipamorelin with the multi-day DAC form would mismatch the timescales a minutes-long pulse riding on a days-long baseline and the DAC form additionally carries the noted safety history