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GLP-1 receptors are present in vascular tissue, and their activation may improve endothelial function

GLP-1 inhibits High-Glucose-Induced oxidative injury of vascular endothelial cells

Injections that include a local anesthetic may have a near-immediate effect while other agents may take several days to have an effect

Reutens AT, Jandeleit-Dahm K, Thomas M et al (2020) A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: protocol and statistical considerations