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Of significance, there is growing evidence that the reversible formation of mixed disulfides between GSH and low-pKa cysteinyl residues of proteins ( S -glutathionylation) is an important mechanism for dynamic, posttranslational regulation of a variety of regulatory, structural, and metabolic proteins, and for the regulation of signaling and metabolic pathways in intact cell systems (Dalle-Donne et al., 2007

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In gastrointestinal malignancies, particularly during Helicobacter pylori infection, SLFN4 expression is upregulated and associated with the expansion of SLFN4 + MDSCs in the gastric TME