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Moreover, mitochondrial dysfunction causes diminished energy metabolism, alterations in the key enzymes in oxidative phosphorylation, dysregulation of calcium homeostasis, and elevated levels of sporadic mutations in the mtDNA in AD [41]

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[60] Low muscle tone (hypotonia) can be a sign of many underlying conditions, including vitamin deficiencies (B1 and other B vitamins), hypothyroidism, carnitine deficiency, creatine deficiency, and methylation issues, as well as genetic conditions (of which there are hundreds)