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In recent years, research on novel drugs targeting ferroptosis for antitumor effects has intensified, and traditional Chinese medicine and researchers, both domestically and internationally, have shown great interest in their monomer components because of their excellent therapeutic effects and reduced toxic side effects 27

These tend to be most pronounced during the dose escalation period and generally improve over time

In the presence of redox-active transition metals, VC exhibits pro-oxidant effects, inducing oxidative stress through the formation of ROS or by inhibiting the antioxidant system (39, 97)