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They could still be detected over time until 24 h after injection (Fig

Conversely, starting at excessive doses (500+ mcg) causes unnecessary side effects prompting premature discontinuation before benefits appear

van Buul-Offers et al (1995) have shown that overexpression of IGF-2 in transgenic normal and pituitary deficient Snell dwarf mice causes increased growth of the thymus, suggesting a role for IGF-2 in thymic development by paracrine or autocrine mechanisms

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