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Contact your healthcare provider if you experience: Severe or persistent heartburn that does not respond to appropriate treatment within two weeks Difficulty swallowing (dysphagia) or painful swallowing (odynophagia) Weight loss that seems excessive or occurs more rapidly than expected with treatment Persistent nausea or vomiting that prevents adequate nutrition or hydration Vomiting blood or material that looks like coffee grounds Black, tarry stools suggesting gastrointestinal bleeding Severe abdominal pain , particularly if localized to the upper abdomen Right upper abdominal pain, fever, or yellowing of skin/eyes , which may suggest gallbladder disease Signs of dehydration such as extreme thirst, dizziness, or decreased urination after significant vomiting or diarrhea Seek emergency care immediately (call 911) if you experience: Chest pain , especially if accompanied by shortness of breath, sweating, or radiation to the arm or jaw Severe, persistent abdominal pain radiating to the back , which may indicate pancreatitis Pancreatitis is a known risk with GLP-1 receptor agonists including tirzepatide, as noted in the FDA prescribing information

F., Ransohoff, R

Patients on semaglutide can worry less about falling victim to random urges, because those urges wont arise

J Nucl Med 40:1716