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Although slightly more studies reported muscle cramps or digestive issues with creatine, the number of affected participants was very low (fewer than 1% in both cases)

Mechanical Injection Variables Injection-related variables can influence local response, including: Shallow (intradermal) placement instead of subcutaneous Injecting too quickly Larger volume in a small surface area Repeated use of the same anatomical site Even sterile saline alone can produce a temporary raised bump if placed too superficially