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Concomitantly, HIF-1 suppresses mitochondrial fatty acid oxidation by downregulating c-Myc and its targets, medium-chain and long-chain acyl-CoA dehydrogenases(MCAD/LCAD) and inhibiting the PTEN pathway (98, 99)

HIV lipodystrophy patients showed about 15.2% visceral fat reduction at 26 weeks versus placebo, plus favorable lipid and trunk-fat changes

The first step is rate-limiting and subject to feedback inhibition by glutathione itself, holding intracellular concentrations in the low millimolar range, typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999

10.1177/17562848231170946 4 ArmandiA.BugianesiE