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For patients who cannot tolerate the target dose, stepping back one dose tier and holding for four to eight additional weeks is preferred over immediate discontinuation

Nausea is the most common complaint, although vomiting, diarrhoea, constipation, abdominal discomfort and reduced appetite may also occur

Semaglutide can cause a modest increase in heart rate (average 2-4 beats per minute), and excessive caffeine may compound this effect

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