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Apart from DSePA, our group has also studied the radioprotective activity of another organoselenium compound, dihydroxy-1-selenolane (DHS), which was earlier reported for GPx-like activity under in vitro conditions by Iwaoka and co-workers [93, 94]

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The result: severe water retention, numbness and tingling in the hands (carpal tunnel symptoms from excessive GH), facial flushing, and paradoxically reduced GH output as the pituitary downregulates its response