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Below find WHO recommendations on obesity & GLP-1 therapy: Recommendation 1 In adults living with obesity, GLP-1 therapies may be used as a long-term treatment for obesity

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Homocystinuria (a high level in the urine) or severe hyperhomocysteinemia (a high level in the blood) is a rare autosomal recessive disorder characterised by severe elevations in plasma and urine homocysteine concentrations

Patients with pre-existing depression or anxiety should have mental health monitoring during orforglipron therapy, and any new mood symptoms should be reported promptly