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Meaningful results typically appear within the first eight weeks as doses reach the 0.5 to 1.0 mg range, with significant outcomes developing over three to six months of sustained use

Further research is needed to establish standardized protocols for PRP administration and identify patients most likely to benefit from this treatment

Upon successful model establishment, GABA (20mg/kg/day) was administered by gavage to the treatment group, and the TS group received the same volume of normal saline for 4 weeks

Oxidative stress can trigger intracellular signaling pathways, resulting in the upregulation of genes expression associated with inflammation [56]