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Locked by the conserved disulfide bond (C46-C71) with the N-terminal -helix, 1 strand (residues 61 to 77) of GLP-1R ECD also shifted towards ECL1 by 9.3 (measured at the C of E68)

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Human GLP1R mRNA positive cells are localised in the hypothalamus, hippocampus, thalamus, caudateputamen, globus pallidum and cerebral cortex [41], and human postmortem brain studies have revealed the presence of GLP1R in the brainstem, hypothalamus, thalamus, amygdala, hippocampus and cerebral cortex [41, 42, 43]