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Further studies with longer assessment periods are needed for both preclinical and clinical studies because of these contrasting findings

A Phase IIb study comparing cotadutide with the GLP-1R mono-agonist liraglutide showed that, after 54 weeks, cotadutide produced similar HbA 1c reductions (cotadutide vs liraglutide: 13.0 mmol/mol vs 12.8 mmol/mol [1.19% vs 1.17%]) but greater bodyweight reductions than liraglutide (5.02% vs 3.33%) [6]

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GSH protects cellular mitochondria by clearing environmental toxins and binding to heavy metals as a natural chelator