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Al-khawalde AAmarddyahA, Abukhalil MH, Jghef MM, Alfwuaires MA, Alaryani FS, Aladaileh SH, Algefare AI, Karimulla S, Alasmari F, Aldalin HK, Alanezi AA, Althunibat OY (2022) Punicalagin protects against the development of methotrexate-induced hepatotoxicity in mice via activating Nrf2 signaling and decreasing oxidative stress, inflammation, and cell death

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The skin connection largely comes down to melanin