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In infants, pyridoxine deficiency can cause irritability, abnormallyacute hearing, and seizures, which are unresponsive to anticonvulsants but respond to pyridoxine supplementation ( A study performed by Yang and Wang in 2009 showed in-vivo study that pyridoxine can inhibit glutamate release from cerebrocortical synaptosomes by suppressing voltage-dependent Ca2+ entry

Bibcode:2007JAFC...55.6466E

In multiple experimental models, researchers have observed increased migration markers in endothelial and epithelial cells when thymosin beta-4 pathways are active