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Experimental models show increased cyclic AMP levels in adipocytes, indicating activation of second messenger systems typically linked to -adrenergic signaling

By subtracting the enteroid epithelial gene count data (n = 2445 genes), after overlaying it on Recon3D from the gene count data from RISK (n = 3193 genes), we inferred that 748 genes are likely to be related to functions outside of the epithelium that are not represented in enteroids but would be present in an ileal biopsy

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Understanding BDNFs role in brain health illuminates why targeting this pathway from multiple angles produces enhanced outcomes