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In order to determine whether the genes found to be altered in the immortalized hypothalamic cell line were also expressed in the LH in vivo and altered by ingestion of fat, chow or sucrose, rats were exposed to respective diets for 1 h per day for 1 week on an every other day schedule

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The intent of this change is to drive improved health outcomes, which could have substantial benefits and downstream impacts, but if enacted, the proposed changes will expand coverage criteria, significantly impacting health plans in quick time