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Several ophthalmologists and public health advocates are now urging the agency to require a black box warning on semaglutide drugs, including Ozempic, Wegovy, and Rybelsus, in light of mounting evidence linking them to nonarteritic anterior ischemic optic neuropathy (NAION)

Patients with severe gastrointestinal motility disorders (such as gastroparesis), history of bowel obstruction, or significant abdominal surgical history should discuss their potential increased risk with their provider before starting weight loss injections

These include anaphylaxis, angioedema, rash, and urticaria

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