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Contrave: This medication, which combines naltrexone and bupropion, works to suppress appetite and support weight loss

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Contact your prescriber if: you experience severe or persistent nausea that prevents eating for more than 48 hours, you notice signs of pancreatitis (severe abdominal pain radiating to the back), you develop symptoms of gallbladder problems (sharp upper right abdominal pain after eating), you experience persistent vomiting that does not respond to dietary modifications, you have a known history of medullary thyroid carcinoma or MEN 2 syndrome (semaglutide is contraindicated), or you develop an allergic reaction (rash, swelling, difficulty breathing) at any point