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Key Takeaway More people than ever are managing their health with GLP-1 receptor agonists and more of them are traveling with these medications every day

This presents without the classic heartburn but causes persistent throat clearing, a chronic cough that worsens after eating, hoarseness, a feeling of a lump in the throat, or worsening asthma symptoms

Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks

Semaglutide This is a GLP-1 agonist - and is the active ingredient or drug in Ozempic and Wegovy