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Barrier permeability is evaluated by detecting indicators such as transepithelial electrical resistance (TEER) and fluorescein sodium permeability

These effects are consistent with lower thrombo-inflammation, slower progression toward myelofibrosis and decreased leukemic transformation risk

Treatment typically continues for at least one year, often longer, making annual costs potentially exceed $15,000 without coverage

Phase 2 clinical trials have demonstrated that GLP-3 can reduce body weight by up to 24.2% over a 48-week period, while also improving cardiometabolic parameters such as blood pressure, lipid profile, and insulin sensitivity