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In STEP UP, the 7.2 mg dose produced an average weight loss of 20.7% over 72 weeks, compared with 17.5% on 2.4 mg, while going from no medication to 2.4 mg added far more than that

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Signs of frank nutrient deficiency include fatigue beyond expected levels, excessive hair loss, skin flakiness or itching, muscle weakness, poor wound healing, and unusual bruising [59]

However, those benefits come at a significant financial cost, with annual treatment expenses typically ranging from $12,000 to $16,000 per patient. GLP1 coverage is one of the most consequential benefit decisions employers will face in 2026