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The post says pharmaceutical companies directed resources toward oral semaglutide and tirzepatide tablets rather than transdermal systems, because those provide more stable absorption profiles and easier dose titration compared with patches that must overcome skin variation and patient adherence challenges

10.1016/j.phymed.2025.157030 Summary Keywords 5-aminosalicylic acid, combination therapy, naturalbioactive compounds, synergistic effect, traditional Chinese medicine, ulcerative colitis Citation Dong W, Wu H, Liu T and He W (2026) Advancing ulcerative colitis therapy: a review of 5-ASA synergy with traditional Chinese medicine and natural bioactive compounds