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These results are internally replicated across orthogonal rescue experiments (including MCT4 re-expression) and are among the clearest causal examples that an epitranscriptomic enzyme can dial the TME toward or away from immunosuppression ( Chemokine circuits supply a second, tumor-intrinsic route from m 6 A to infiltration phenotypes, but here the direction of effect is context-dependent
Apoptotic death of photoreceptors in the streptozotocin-induced diabetic rat retina
Aggregation or precipitation in solution, reducing available monomeric peptide
While the number of particles in the second reconstruction was much lower than the first, the data were consistent with a lower number of particles in a CT-like conformation (~ 17% of particles) relative to the bypass conformation (55% of particles) compared to the percentage of particles previously observed for the Amy-CTR-Gs complex (note, in the repeat experiment 28% of the particles could not be confidently classified, due to poorly resolved in ECD features) (Supplementary Fig
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