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After this interaction, glutathione is transformed from its reduced form to its oxidized one

One of the leading mechanisms of astrocyte-associated neurotoxicity is associated with severe decrease in the expression of glutamate transporters, the presence of which is reduced, in ALS patients, to only ~10% of the levels in healthy subjects

Radzikowska, U

To this degree, there are a low number of fingolimod associated malignancies that have emerged in clinical trials (Table 1) and in the post-clinical trial era, including melanoma, basal cell carcinoma, breast cancer, squamous cell carcinoma, large B cell lymphoma, ocular lymphoma, Merkel cell carcinoma, cutaneous CD30+ T-cell lymphoma and multiple myeloma