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Key findings include: (1) Diverse Mechanisms : Plants like cinnamon (cinnamaldehyde), bitter melon (karavilagenine E), and ginseng (ginsenosides) modulate GLP-1 via DPP-4 inhibition, receptor activation, and SCFA production, offering multi-targeted effects beyond glucose control

Weight loss, which commonly occurs with tirzepatide therapy, can influence hormonal balance and thermoregulation, though evidence suggests that weight loss may actually improve vasomotor symptoms in some overweight postmenopausal women

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Estrogens and androgens protect mitochondria against the degenerative effects that occur with aging (208)