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This provides an explanation for the involvement of neurexins proteins in the mechanism of sustained antidepressant effect mediated by BDNF signaling, but recent studies have not clarified their relative upstream and downstream relationship to BDNF signaling, and the mechanism of this regulation at the protein level awaits further clarification

Much of the published work on it comes from animal and lab studies, not from large human trials

However, the baseline GLP-1 sensitivity was not exactly evaluated because the baseline hyperglycemic clamp was performed 2 to 7 days after treatment initiation [37]

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