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As a result of these and other factors, pain sensitivity increases after long-term nicotine exposure

At the initial assessment visit (week 0), participants will receive travel reimbursement but no monetary compensation

These figures allowed us to observe the county-level sales impact of the two changes in state cigarette taxes that occurred during this 33-month period: Indiana's cigarette tax increase from 55.5 cents per pack to 99.5 cents per pack in July 2007, and Wisconsin's cigarette tax increase from 77 cents per pack to $1.77 per pack in January 2008