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Pharmacokinetic endpoints: if the research objective includes PK characterisation, build in LC-MS quantification of serum peptide at multiple timepoints to generate a concentration-time curve
Editors note: If youre an elite athlete, be aware that semaglutide is currently on the WADA Monitoring Program
Thus, truncation of the C-terminal L585 residue of the GLP-1 fusion containing WT albumin reduces its cellular recycling in vitro and plasma half-life in vivo, which may be compensated for by QMP engineering of albumin, irrespective of the presence of L585
If you were using GLP 1 purely for weight loss and then found out youre pregnant, this study is somewhat reassuring but these drugs are still not recommended in pregnancy
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