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Metabolomic profiling was restricted to plasma, and the combined nature of the dietary intervention precludes attribution of effects to individual dietary components

However, HeLa cells are much more sensitive, with 2.5 nM (per million cells) of doxorubicin resulting in up to 80% GSH depletion for the same exposure time 38

a number of other patents and patent applications contain prophetic disclosures of combination therapy where one agent is a melanocortin receptor agonist and a second agent is a PDE-5 inhibitor