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Moderately and severely affected individuals have enzymes with dysfunctional catalytic sites, rendering it unable to participate in detoxification reactions

"It's not a panacea, it's not a silver bullet," he added, stressing the importance of dietary changes and physical exercise

Food and Drug Administration and is available only via intravenous infusions, so its not something consumers are likely to get their hands on any time soon, says study coauthor Richard Pratley, a clinician and metabolic disease researcher at the AdventHealth Translational Research Institute in Orlando, Fla

However, under conditions of iron overload, excess Fe 2+ in the LIP undergoes Fenton chemistry with H 2 O 2 , producing excessive ROS, promoting lipid peroxidation, and ultimately triggering ferroptosis (Zhao et al., 2025a)