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A high-sugar diet appears to raise the risk of kidney stones, which may relate in part to the ability of refined sugar and large quantities of carbohydrate to elevate urine calcium (Thom 1978

In the study by in vitro on anaplastic thyroid cells, it was demonstrated that the treatment with rosiglitazone reduced anchorage-dependent and -independent growth and migration of TC cells, and increased apoptosis rate by reducing Bcl-X(L) expression and caspase-3 and -7 activation

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However, MRP1 is unlikely to adopt the ATP-dependent transition from inward to outward conformation to transport a single molecule of GSH, because if such was the case, a strong stimulated GSH efflux would require the hydrolyzation of a large number of ATP, and this would not comply with the very low ATPase activity of MRP1 57