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In human hippocampal progenitor cells, the IL-1-induced increases in KP enzymatic activity and the subsequent dampening of neurogenesis was reversed with co-treatment with a KMO inhibitor, which would reduce the levels of 3-HK and QA [116]

13 Its depletion has been associated with enhanced toxicity of many compounds that cause increased morbidity or death

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(1) Studies on the Validation of In Vivo Obesity Intervention Effects A large number of in vivo animal experiments have confirmed that it exerts significant weightloss and fatreducing effects with favorable safety profiles.In a mouse model of highfat dietinduced obesity, administration of 20 mg/kg NNMTi daily for 11 days resulted in a significant reduction in body weight