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doi: 10.1186/s12888-020-03019-8 75 ThyrionLPortelliJRaedtRGlorieuxGLarsenLESprengersMet al

The ability of IL-1 to induce chondrocyte catabolism [121] has been well known for a long time, but it is only recently that IL-1 has been shown to disrupt chondrocyte iron homeostasis [117] and trigger chondrocyte ferroptosis [22, 122]

Prevents damage from free radicals and reactive oxygen species

Moreover, although the microbiome reached an adult-like stability at around 2 years of age, important taxonomic and functional changes did occur both before and after adolescence