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Smoking causes deposition of nicotine and tar inside the arteries of the heart, brain and all the blood vessels, this leads to heart attacks, strokes and peripheral vascular diseases." The doctor believes that smoking even a single cigarette increases your risk of heart attack by many times, since it is so "deleterious" and says that every cigarette shortens your life by 5 to 7 minutes

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There is a framework for preclinical studies, proposing in vitro tests of genotoxicity, oxidative stress, and inflammation