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And as established in the previous section, it plays an active role in neuronal energy metabolism and mitochondrial function

This biochemical cascade contributes to DPN through oxidative stress and inflammation, damaging nerves over time and ultimately leads to nerve fiber injury and degenerationhallmarks of diabetic neuropathy

In such a situation, one of the largest obstacles is that most of the GLP-1 receptor antibodies which are available now are not working very well in several experiments including immunostaining and western blotting

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