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The presence of GLP-1R in MCs has been confirmed by multiple research groups, including our own 5,15,16 and ex vivo data have shown that MCs increase their action potential firing frequency after the addition of both GLP-1 and the GLP-1R agonist exendin-4 17

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Dose adjustments of other antidiabetic agents may be necessary when initiating GLP-1 receptor agonists

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