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Lancet 374:16061616 DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD (2005) Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes

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ER stress activation can mitigate protein synthesis, induce ER chaperones to facilitate protein folding, and increase ER-associated degradation to reduce protein load

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