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However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program
Nitrous oxide (used in anaesthesia or misused recreationally) inactivates vitamin B12 and can precipitate or worsen neurological injury in patients with B12 deficiency
Similarly, caffeine can interact with the absorption of B12, as it influences the digestive system and might exacerbate feelings of discomfort post-injection
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