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Sikiric et al., 2020b) without toxicity (lethal dose 1 (LD1) could be not obtained) (Sikiric et al., 1993
Previous studies demonstrated that administration of leptin in hypothalamic nuclei increases glucose uptake by BAT, raises BAT temperature, and increases UCP1 expression [31,32,33], the main protein involved in mitochondrial uncoupling and heat generation in BAT
84 A phase I trial assigned approximately 50 participants with a BMI between 30 and 40 kg/m 2 without diabetes to single ascending dose (SAD), multiple ascending doses (MAD) or placebo
Decreased expression of the GLP-1 receptor after segmental artery injury in mice
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