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Itohan Omorodion, MD, MPH, is an internal medicine resident at George Washington University Hospital and a member of the ABC News Medical Unit

DPP-4 inhibitors [37], which elevate incretin hormone levels to maintain glucose homeostasis, have yielded mixed findings regarding their association with intestinal obstruction: a smaller study of 40,615 patients indicated a potential risk [15], while a larger cohort study of 190,321 patients across three countries found no increased risk [16]

Although, a mixture of treatments can be used for targeting different problem areas

The inhibition of SIRT1 activity can induce cardiomyocyte apoptosis by increasing p53 acetylation and upregulating Bax expression