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At the beginning of the study, the average weight and BMI of patients was 106 kg and 38 kg/m 2, respectively, with approximately 81% considered severely obese (120% of the 95 th percentile or greater for BMI standardized by age and sex)

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Possible ivermectin resistance mechanisms In nematodes, extensive research has indicated that common mechanisms of resistance include GluCl mutations, changes to ABC transporter expression, and through upregulation of detoxification genes (Dent et al